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doi: 10.1039/C3FO60400D

Concordant with this hypothesis, we observed that IFN- was important in SerpinB2 reduction in obesity, and the anti-apoptotic role of SerpinB2 has been demonstrated in inflammatory disease pathologies 137,138,139,140,141,142,143,144,145,146

The gene was subcloned into the BacMam vector 60 , with a C-terminal eGFP and PreScission cleavage site, using primers (Fwd: CCACTCCCAGTTCAATTACAGCTCTTAAGGGCCACCATGCGGGACTACGACGAGG and Rev: CAGCACTTCCAATCTAGATTCGAAAGCGGCGCCGAAGGCTGTGCTTTTAAGGATT

Glutathione peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate

However, with the depletion of GSH in liver cells, reactive metabolites gradually accumulate, resulting in cytotoxicity, which eventually leads to liver cell necrosis and acute liver failure (Figure 3)

This reactive metabolite produces conjugation adducts for many cellular proteins, including those involved in the mitochondrial ETC and others [110, 268, 269]